Metaregul

Reason of the choice of components

The quercetin

A flavonoid, i.e one of the numerous pigments which give their color to fruits, vegetables and to medicinal plants.

In nature, quercetin is often linked to the vitamin C which improves the absorption by the body.

Quercetin is considered to be the most active flavonoids.

The quercetin is extracted from diverse vegetable sources, in particular from seeds and from pods of Dimorphandra mollis, a tree of the legumes family, native of South America, as well as the peel of onions.

It has properties of antioxidants, anti-inflammatory and antihistaminic (anti-allergic) confirmed in animals.

Quercetin has positive effects on the capillaries and cardiovascular system.

Flavonoids are natural compounds of the family of polyphenols.

Most of these compounds show interesting biological activities such as anti-oxidizing and anti-radical actions. Indeed, by complexing with specific enzymes, flavonoids are able to metabolize dioxygen.

The chromium 

Normalizes insulin function and regulates sugar level. It reduces the demand of insulin in diabetics. As part of the metabolic syndrome, it decreases those of pre-diabetes of type two, the glucose intolerance and the insulinic resistance. It plays a cofactor role with insulin.

Secondarily, it helps burn fats and increase muscle mass, lowers LDL cholesterol and increases HDL cholesterol

The vitamin B6

is a water-soluble vitamin.

It is involved in over sixty enzymatic systems participating in protein metabolism.

Vitamin B6 participates in the synthesis of amino acids and is essential for the synthesis of niacin from tryptophan.

This vitamin also regulates the release of hepatic glycogen from the muscles needs. It participates in the production of insulin, hemoglobin and antibodies.

Vitamin B12

Also called cobalamin contains a metallic ion (cobalt). This vitamin can be only synthetized by bacteria and, so, is mainly present in products of animal origin. Vitamin B12 contributes to the formation of blood cells and the marrow, the metabolism of carbohydrates, fats and proteins and to the production of genetic material. It also assists the nervous and cardiovascular mechanisms and plays a role in the synthesis of DNA.

Vitamin B12 plays a role in preventing accumulation of homocysteine, reducing the risk of cardiovascular disease. The medical inhibitors of gastric acid may decrease the absorption of vitamin B12 in the diet, as well as antilipemic medicines.

Vitamin B12 intervenes in many enzymatic processes, as well as in the metabolism of lipids and carbohydrates, phosphorus and glutathione which exercises in the body the role of hydrogen carrier.

Spirulina contains 3 times more vitamin B12 than raw calf liver. It should be noted that a variable proportion (but strong) of this B12 is in fact composed of B12 analogues, non-assimilated by the man.

The Acerola

is rich in vitamin C (1800mg/100g) : it contains 20-30 times more than oranges.It has an anti-inflammatory action. It increases resistance to stress through its action on the adrenal glands. 

The Ribes nigrum

The leaves contain a little essential oil, numerous flavonoids and prodelphinidins. The anthocyanosides of fruit have a vasculoprotective and anti-edematous activities as well by oral way as by parenteral way in animals. Biological tests indicate that these substances decrease capillary permeability and increase their resistance. 

They are also free radical scavengers. The prodelphinidins of the leaves show an anti-inflammatory activity by increasing adrenocortical activity.

Vitis vinifera

The vine rich in flavonoids (more than 4%) is responsible for the famous French paradox, which shows a lower rate of cardiovascular disease in wine regions despite similar cholesterol levels or even higher than in other regions.

The most plausible explanation is an antioxidant role due to these flavonoids and among others the kaempferol-3-O-glucosides, quercetin-3-O-glucosides and especially to the richness of the wine tannins.

Along with this antioxidant effect, the anti-inflammatory role and vascular protective of the flavonoid of the vine leaf has long been known.

Flavonoids act on the cardiovascular system. They increase the peripheral circulation, dilate the coronary vessels, influence the hemostasis and reduce blood pressure. Flavonoids protect the tissular cells from damage of the radiation and they interfere in the release by the cells, "mast" of mediators playing a role in allergic reactions and inflammatory. They also have inhibitory properties of platelet aggregation.

Anti-inflammatory effects of flavonoids have been demonstrated. The flavonoids have an inhibitory effect on the biosynthesis of prostaglandins. The prostaglandins (formed by the way of the cyclooxygenase) and leukotrienes (formed through the lipoxygenase) are metabolic Biologically active of the arachidonic acid which play an important role in the complex inflammatory process.

Allium cepa

Present hypoglycemic properties. Clinical trials are few on its hypoglycemic action. A preliminary study (20 diabetic subjects) published in 1983 suggests that consumption of allium, can significantly lower the blood glucose. The results of a study led on diabetic rats indicate that compounds in garlic and onion may have insulin-like action. It is the amino-sulfoxides compounds which can protect the circulating insulin against the degradation and also stimulate its production by the pancreas.

The Melissa binds to muscarinic and nicotinic acid to act on muscarinic receptors. This mechanism suggests a positive action in Alzheimer's disease.