RDBT

It is also frequent during the diabetes mellitus type 1 (insulino-dependent) as during the type 2 diabetes often associated, him, with an arterial high blood pressure and an obesity.

The incidence of retinopathy of type 2 diabetes increases with age because the vascular lesions are directly dependent on the duration of hyperglycemia

All diabetics should be monitored at the level of the retina :

- In the absence of retinopathy or minimal retinopathy, an annual review is sufficient

- In case of graver retinopathy, a monitoring every 4-6 months may be necessary.

The beneficial effect on retinopathy of a good glycemic control has been demonstrated in diabetic of type 1 and 2, with also a beneficial effect, of a well-balance blood pressure for the diabetics of type 2.

Indeed, the diabetic retinopathy is directly the consequence of duration the hyperglycemia because in that case, there is activation of the way of the aldose reductase, accumulation of sorbitol and fructose in intracellular and phenomena of increased protein glycation. Ie the attachment of sugars on amino acids composing proteins (glycosylation) and then denatures these proteins that can not fulfill their roles or be eliminated and which therefore accumulates.

These glycosylated proteins leads to the development of free radicals who damage the tissular structures, in particular here, the internal wall of small vessels and causing a depletion of glutathione. It leads to a bigger quantity of not neutralized free radicals etc...

It has been shown that diabetic patients with retinopathy have a higher levels of oxidation product called malondialdehyde compared to also those diabetic without retinopathy and with a better control of their glycemia.

But also of :

- The alpha lipoic acid of form R which prevents protein glycosylation, inhibits the aldose reductase, is a powerful antioxidant both in aqueous and lipid, allows the direct regeneration of vitamin C and indirect Vitamin E, which allows to increase the intracellular levels of glutathione and coenzyme Q.

- the Quercetin because of its antioxidant property and especially inhibitive of the aldose reductase..(21)

- the Magnesium because of low levels of magnesium, essential for vascular integrity, were found lower at many diabetic with retinopathy.

- the Vitamin B6 which may have a preventive role (22)

- Zinc because two important enzymes necessary require it for the proper functioning in retinal.

- the lutein which seems more suitable than the beta carotene, and which constitutes the main carotenoids antioxidant of the retina

- acetyl-Lcartinine for its anti-glycation role amply demonstrated by its very favorable use and already ancient in diabetic neuropathy.

Finally :

- the Ruscus of which he was shown the action more favorable than the troxerutin in the complications of microangiopathy (23)

- Vaccinium myrtillus of at least 25% of anthocyanosides, which have a stabilizing effect on the connective tissue, 23, which decrease capillary fragility by a powerful anti-oxidant effects and have a special affinity for the retina.

- and Ginkgo biloba which it was shown that it can improve the color vision among patients with advanced retinopathy (24)

Therefore improve blood flow, normalize the levels of glycemia and correct the underlying metabolic disturbances are the three main objectives that should aim to achieve the therapeutic management complementary of the diabetic retinopathy.

Daily protocol of  Diabetic Retinopathy :

- RDBT : 2 caps (combination of  R alpha lipoic acid, Ruscus aculeatus, Vaccinium myrtillus at  25%  of anthocyanosides, Ginkgo biloba, Lutein, B6, Zinc, acetyl L cartinine, Quercetin) associated with ...
- SEVINE : 2 caps
- MALATE MG  : 2 caps
- AC500 : 2 caps
& only for Type 2 diabetes, completed by ...
- METAREGUL : 1 cap